Can I use a deodorizer urinal screen with fragrance? Or will this mess with the blue sealant?

No blue sealant is needed with this Waterless Urinal Cartridge. You can use any urinal screen. The suggested maintenance for this waterless urinal screen is to clean with any cleaner or detergent at the end of the day and then flush 1 gallon of water down the waterless urinal to flush out any remaining urine.
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